P/D1 cell explained

P/D1 cells are cells lining the fundus of the human stomach that produce ghrelin. Removal of these cells in gastric bypass surgery has a profound impact on later appetite regulation.[1] These cells have also been shown to produce ghrelin's antagonistic hormone leptin.[2] PD/1 cells are equivalent to A-like cells in rats and X-type cells in dogs. These endocrine cells can be microscopically distinguished from other gastric endocrine cells through their round, compact, electron-dense secretory granules.[3]

Notes and References

  1. Inui A, Asakawa A, Bowers CY, etal . Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ . FASEB J. . 18 . 3 . 439–56 . 2004 . 15003990 . 10.1096/fj.03-0641rev . free . 15642270 .
  2. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ . 1998 . The stomach is a source of leptin . Nature . 394 . 6695. 790–793 . 10.1038/29547 . 9723619 . 1998Natur.394..790B . 4367948 .
  3. Sakata . Ichiro . Sakai . Takafumi . Ghrelin Cells in the Gastrointestinal Tract . International Journal of Peptides . 14 March 2010 . 2010 . 1–7 . 10.1155/2010/945056 . 20798855 . 2925405 . free .

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