Oxipurinol Explained

Oxipurinol (INN, or oxypurinol USAN) is an inhibitor of xanthine oxidase.[1] It is an active metabolite of allopurinol and it is cleared renally.[2] In cases of renal disease, this metabolite will accumulate to toxic levels. By inhibiting xanthine oxidase, it reduces uric acid production. High serum uric acid levels may result in gout, kidney stones, and other medical conditions.

Notes and References

  1. The pharmacokinetics of oxypurinol in people with gout. British Journal of Clinical Pharmacology. 74. 3. 477–489. 10.1111/j.1365-2125.2012.04207.x. 22300439. 3477349. 2012. Stocker. Sophie L. McLachlan. Andrew J. Savic. Radojka M. Kirkpatrick. Carl M. Graham. Garry G. Williams. Kenneth M. Day. Richard O.
  2. Renal clearance of oxipurinol, the chief metabolite of allopurinol. The American Journal of Medicine. 45. 1. 69–77. 10.1016/0002-9343(68)90008-9. 5658870. 1968. Elion. Gertrude B. Yü. Ts'ai-Fan. Gutman. Alexander B. Hitchings. George H.

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