Oxycodegol Explained

Oxycodegol (also known as loxicodegol and NKTR-181) is an experimental μ-opioid receptor agonist for the treatment of pain.[1] [2] It has had success for back pain as an alternative to traditional opioids,[3] which have potential for abuse. It acts more slowly on the central nervous system, reducing risk for abuse and respiratory depression.[1]

Notes and References

  1. Book: Advokat . Claire D. . Comaty . Joseph E. . Julien . Robert M. . Julien's Primer of Drug Action: a comprehensive guide to the actions, uses, and side effects of psychoactive drugs . 2019 . . New York . 978-1-319-20054-1 . 565.
  2. Web site: NKTR-181 (Oxycodegol) Oral Tablets for. Chronic Low Back Pain . . https://web.archive.org/web/20201224101145/https://www.fda.gov/media/134084/download. 24 December 2020.
  3. Markman . John . Gudin . Jeffrey . Rauck . Richard . Argoff . Charles . Rowbotham . Matthew . Agaiby . Eva . Gimbel . Joseph . Katz . Nathaniel . Doberstein . Stephen K . Tagliaferri . Mary . Lu . Lin . Saddhanti . Suresh . Hale . Martin . SUMMIT-07: a randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain . PAIN . June 2019 . 160 . 6 . 1374–1382 . 10.1097/j.pain.0000000000001517 . 30747908 . 6553961 .

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