Oxolinic acid explained

Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s.[1] [2] Dosages 12–20 mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.[3]

See also

Notes and References

  1. JP Patent 49138244
  2. Gleckman R, Alvarez S, Joubert DW, Matthews SJ . Drug therapy reviews: oxolinic acid . American Journal of Hospital Pharmacy . 36 . 8 . 1077–9 . August 1979 . 384788 .
  3. Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J . Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor . European Neuropsychopharmacology . 8 . 4 . 255–9 . December 1998 . 9928913 . 10.1016/S0924-977X(97)00083-7. 22626555 .

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