Oxetacaine Explained

Oxetacaine (INN, also known as oxethazaine) is a potent local anesthetic. It is administered orally (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis. One example of such a product is Mucaine Gel, indicated for "rapid and effective relief in gastritis, esophagitis, hiatus hernia, heartburn of pregnancy and peptic ulcer".^[1] It is also used topically in the management of hemorrhoid pain. Oral oxetacaine preparations are available in several countries, including India, South Africa, Japan, Taiwan and Brazil, but not the United States. Unlike most local anesthetics, oxetacaine does not break down under strongly acidic conditions.^[2]

It is known to produce mephentermine and phentermine as metabolites.^{[3] [4]}

External links

• Strocain Prescribing information from Eisai Co.

Notes and References

1. Web site: Mucaine Gel . Pfizer.com . Pfizer . 6 October 2022.
2. Seifter J, Glassman JM, Hudyma GM . Oxethazaine and related congeners: a series of highly potent local anesthetics . Proc Soc Exp Biol Med . 109 . 664–8 . 1962 . 3 . 13910333 . 10.3181/00379727-109-27300. 39641018 .
3. Hsu MC, Lin SF, Kuan CP, Chu WL, Chan KH, Chang-Chien GP . Oxethazaine as the source of mephentermine and phentermine in athlete's urine . Forensic Sci Int . 185 . 1-3 . e1–5 . March 2009 . 19157735 . 10.1016/j.forsciint.2008.12.009 .
4. Huang WH, Liu CH, Liu RH, Tseng YL . Confirming urinary excretion of mephentermine and phentermine following the ingestion of oxethazaine by gas chromatography-mass spectrometry analysis . J Anal Toxicol . 34 . 2 . 73–77 . March 2010 . 20223098 . 10.1093/jat/34.2.73 .