Oxendon was a rural district in Northamptonshire, England from 1894 to 1935.
It was formed under the Local Government Act 1894 from the part of the Market Harborough rural sanitary district which was in Northamptonshire (the rest going on to form Market Harborough Rural District in Leicestershire). It was named after Great Oxendon.
The rural district contained 19 civil parishes:
The district was abolished in 1935 under a County Review Order. It was split between Brixworth Rural District and Kettering Rural District.