Oxalate—CoA ligase explained

Oxalate—CoA ligase
Ec Number:	6.2.1.8
Cas Number:	37318-57-3
Go Code:	0050203

In enzymology, an oxalate—CoA ligase is an enzyme that catalyzes the chemical reaction

ATP + oxalate + CoA

\rightleftharpoons AMP + diphosphate + oxalyl-CoA

The 3 substrates of this enzyme are ATP, oxalate, and coenzyme A (CoA), whereas its 3 products are AMP, diphosphate, and oxalyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is oxalate:CoA ligase (AMP-forming). Other names in common use include oxalyl-CoA synthetase, and oxalyl coenzyme A synthetase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Organisms with Oxalate-CoA Ligases include:
Arabidopsis thaliana^[1]
Saccharomyces cerevisiae^[2]

References

• Giovanelli J . 1966 . Oxalyl-coenzyme A synthetase from pea seeds . Biochim. Biophys. Acta . 118 . 124 - 43 . 4288975 . 1 . 10.1016/s0926-6593(66)80151-0.

Notes and References

1. Web site: A Previously Unknown Oxalyl-CoA Synthetase Is Important for Oxalate Catabolism in Arabidopsis . www.plantcell.org . 2023-09-17 . https://web.archive.org/web/20150924095148/http://www.plantcell.org/content/24/3/1217.full . 24 Sep 2015.
2. 24291261 . 10.1016/j.febslet.2013.11.026 . 588 . An oxalyl-CoA synthetase is important for oxalate metabolism in Saccharomyces cerevisiae . 2014 . FEBS Lett. . 160–6 . Foster J, Nakata PA . 1 . free .