Oxaflozane Explained

Oxaflozane (INN) (brand name Conflictan) is an antidepressant and anxiolytic drug that was introduced by Solvay in France in 1982 for the treatment of depression but has since been discontinued.^{[1] [2] [3] [4]} It is a prodrug of flumexadol (N-dealkyloxaflozane; 2-(3-trifluoromethylphenyl)morpholine; CERM-1841 or 1841-CERM), which is reported to act as an agonist of the serotonin 5-HT_1A (pK_i = 7.1) and 5-HT_2C (pK_i = 7.5) receptors and, to a much lesser extent, of the 5-HT_2A (pK_i = 6.0) receptor.^[5] In addition to its serotonergic properties, oxaflozane may also produce anticholinergic side effects at high doses, namely in overdose.^[6]

See also

• Fluminorex
• Fludorex
• Fenfluramine
• TFMPP
• Befiradol

Further reading

• Rascol A, Maurel H, David J, Layani M . [Preliminary clinical results of a new non tricyclic antidepressive drug: oxaflozane] . fr . Thérapie . 29 . 1 . 95–9 . 1974 . 4603757 .
• Hache J, Duchene-Marullaz P, Streichenberger G . [Pharmacological profile of a new non tricyclic antidepressant: oxaflozane (1,766 Cerm)] . fr . Thérapie . 29 . 1 . 81–93 . 1974 . 4849381 .
• Constantin M, Pognat JF . Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites . Arzneimittel-Forschung . 29 . 1 . 109–14 . 1979 . 582104 .
• Bertolino A, palermo M, Porro V . Un nouvel antidépresseur non tricyclique, l'oxaflozane, dans le traitement des syndromes anxio-dépressifs . Oxaflozane, a new nontricyclic antidepressant in the treatment of anxiety-depressions syndromes . Acta Therapeutica . 11 . 2 . 209–218 . 1985 .
• Aguglia E . On the therapetic value of oxaflozane: Its application in the treatment of emotional disturbances of the anxious-depressive type accompanied by somatic manifestations . Acta Therapeutica . 12 . 3 . 259–268 . 1986 .

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 909–.
2. Book: Swiss Pharmaceutical Society . Index Nominum 2000: International Drug Directory (Book with CD-ROM) . Medpharm Scientific Publishers . Boca Raton . 2000 . 766 . 3-88763-075-0 .
3. Book: Sittig M . Pharmaceutical Manufacturing Encyclopedia . Noyes Publications . Park Ridge, N.J., U.S.A . 1988 . 1122 . 0-8155-1144-2 .
4. Book: Bégué JP, Bonnet-Delpon D . Drugs for CNS Disorders . Bioorganic and Medicinal Chemistry of Fluorine. https://books.google.com/books?id=QMVSvZ-R7I0C&pg=PA303 . 2 June 2008. John Wiley & Sons. 978-0-470-28187-1. 303–.
5. Leysen DC . Selective 5-HT2C agonists as potential antidepressants . IDrugs . 2 . 2 . 109–20 . February 1999 . 16160946 .
6. Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E . Oxaflozane overdose in a child . Journal of Toxicology. Clinical Toxicology . 30 . 1 . 123–6 . 1992 . 1542141 . 10.3109/15563659208994452.