Oviduct-specific glycoprotein explained

Oviduct-specific glycoprotein also known as oviductal glycoprotein (OGP) or estrogen-dependent oviduct protein, oviductin or mucin-9 is a protein that in humans is encoded by the OVGP1 gene.^{[1] [2] [3]}

Function

Oviduct-specific glycoprotein is a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoon acrosomal regions.^[3]

Beyond the oviduct, OVGP1 is detected in the mouse ovary, testis and epididymis suggesting its roles beyond fertilization. It is not detected in the mouse uterus, cervix, vagina, breast, seminal vesicles and prostate gland ^[4] OVGP1 is expressed by the surface epithelium of the endometrium at the time of embryo implantation in the mouse. It is required for maintain the receptivity phenotype and trophoblast adhesion, OVGP1 mRNA levels are reduced in endometrium of women with recurrent implantation failure.^[5]

Sources

• Laheri . Saniya . Ashary . Nancy . Bhatt . Purvi . Modi . Deepak . Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion . Journal of Assisted Reproduction and Genetics . 2018 . 35 . 8 . 1419–1429 . 10.1007/s10815-018-1231-4 . 29968069 . 6086790 .

Further reading

• Verhage HG, Fazleabas AT, Donnelly K . The in vitro synthesis and release of proteins by the human oviduct . Endocrinology . 122 . 4 . 1639–45 . 1988 . 3278893 . 10.1210/endo-122-4-1639 .
• Iontcheva I, Oppenheim FG, Troxler RF . Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins . J. Dent. Res. . 76 . 3 . 734–43 . 1997 . 9109822 . 10.1177/00220345970760030501 . 39525421 .
• Iontcheva I, Oppenheim FG, Offner GD, Troxler RF . Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system . J. Dent. Res. . 79 . 2 . 732–9 . 2000 . 10728974 . 10.1177/00220345000790020601 . 27558675 .
• Agarwal A, Yeung WS, Lee KF . Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter . Mol. Hum. Reprod. . 8 . 2 . 167–75 . 2002 . 11818519 . 10.1093/molehr/8.2.167 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Lok IH, Briton-Jones CM, Yuen PM, Haines CJ . Variable expression of oviductin mRNA at different stages of human reproductive cycle . J. Assist. Reprod. Genet. . 19 . 12 . 569–76 . 2003 . 12503889 . 10.1023/A:1021263132176 . 3455833.
• Chen Q, Zhang J, Sweet F . Homology of primate DNA fragments for estrous-associated oviductal glycoprotein . Hereditas . 139 . 1 . 75–9 . 2004 . 14641477 . 10.1111/j.1601-5223.2003.01640.x . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Woo MM . Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer . Clin. Cancer Res. . 10 . 23 . 7958–64 . 2005 . 15585630 . 10.1158/1078-0432.CCR-04-1261 . Alkushi A . Verhage HG . Magliocco . AM . Leung . PC . Gilks . CB . Auersperg . N . free .
• Ling L . Expression of human oviductin in an immortalized human oviductal cell line . Fertil. Steril. . 84 . 1095–103 . 2006 . 16209999 . 10.1016/j.fertnstert.2005.06.006 . Lee YL . Lee KF . Tsao . Sai-Wah . Yeung . William S.B. . Kan . Frederick W.K. . Suppl 2 . free.
• Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U . Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9 . Mol. Hum. Reprod. . 12 . 4 . 275–82 . 2006 . 16567366 . 10.1093/molehr/gal028 .
• Gregory SG . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . Barlow KF . McLay KE . Kaul . R. . Swarbreck . D. . Dunham . A. . Scott . C. E. . Howe . K. L. . Woodfine . K. . 2006Natur.441..315G . free .

Notes and References

1. Arias EB, Verhage HG, Jaffe RC . Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein . Biol Reprod . 51 . 4 . 685–94 . Feb 1995 . 7819450 . 10.1095/biolreprod51.4.685 . free .
2. Lapensee L, Paquette Y, Bleau G . Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9) . Fertil Steril . 68 . 4 . 702–8 . Nov 1997 . 9341614 . 10.1016/S0015-0282(97)00317-8 . free .
3. Web site: Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin).
4. Laheri . Saniya . Modi . Deepak . Bhatt . Purvi . Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary. . Journal of Biosciences . Mar 2017 . 42 . 1 . 69–80 . 28229966 . 16 July 2018 . 10.1007/s12038-016-9657-2. 10274575 .
5. Laheri . Saniya . Ashary . Nancy . Bhatt . Purvi . Modi . Deepak . Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion . Journal of Assisted Reproduction and Genetics . 2018 . 35 . 8 . 1419–1429 . 10.1007/s10815-018-1231-4 . 29968069 . 6086790 .