| Ousmane Berthé | |
| Birth Date: | 5 February 1987 |
| Birth Place: | Bamako, Mali |
| Height: | 1.85 m |
| Position: | Defender |
| Years1: | –2008 |
| Years2: | 2008–2013 |
| Years3: | 2013–2015 |
| Years4: | 2015–2017 |
| Clubs1: | Centre Salif Keita |
| Clubs2: | Jomo Cosmos |
| Clubs3: | CS Constantine |
| Clubs4: | Muaither SC |
| Caps2: | 89 |
| Caps3: | 36 |
| Goals2: | 4 |
| Goals3: | 1 |
| Clubs5: | Mohammedan |
| Years5: | 2019–2020 |
| Nationalyears1: | 2010–2015 |
| Nationalteam1: | Mali |
| Nationalcaps1: | 18 |
| Nationalgoals1: | 0 |
Ousmane Berthé (born 5 February 1987) is a Malian professional footballer who plays as a defender.
In July 2008, Berthé joined Jomo Cosmos in the South African Premier Soccer League. Berthé played his 1st game on 8 August 2009, for Jomo Cosmos against Platinum Stars, playing 66 minutes before being substituted, the match ended 0–0.[1]