Otter Creek is a stream in Cooper and Morgan Counties in the U.S. state of Missouri. It is a tributary of the Lamine River.
The stream headwaters arise in northern Morgan County northeast of Syracuse and just west of Missouri Route 5 at 38.6769°N -92.86°W at an elevation of about 930 feet.[1] The stream flows to the northwest into Cooper County and on to its confluence with the Lamine River about two miles northeast of Otterville[2] at 38.7264°N -92.9775°W and an elevation of 645 feet.
Otter Creek was so named for the fact it was a hunting ground for otters by pioneers.[3]