| Otsquene Creek | |
| Pushpin Map: | New York Adirondack Park#USA |
| Pushpin Map Caption: | Location of the mouth of Otsquene Creek |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | New York |
| Subdivision Type3: | Region |
| Subdivision Name3: | Central New York Region |
| Subdivision Type4: | Counties |
| Subdivision Name4: | Herkimer, Montgomery |
| Source1 Coordinates: | 42.9644°N -74.7709°W |
| Mouth: | Otsquago Creek |
| Mouth Location: | Valley Brook, New York, United States |
| Mouth Coordinates: | 42.9314°N -74.6722°W[1] [2] |
| Mouth Elevation: | 423feet |
Otsquene Creek is a river in Herkimer County and Montgomery County in the U.S. State of New York. It enters Otsquago Creek by Valley Brook, New York.[3] On the 1905 Fulton and Montgomery County Atlas it is referred to as Crab-skill Creek.