| Official Name: | Otisco |
| Settlement Type: | Unincorporated community and Census-designated place |
| Mapsize: | 120px |
| Pushpin Map: | USA Indiana Clark County |
| Pushpin Map Caption: | Location in Clark County |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Indiana |
| Subdivision Type2: | County |
| Subdivision Name2: | Clark |
| Subdivision Type3: | Township |
| Subdivision Name3: | Oregon |
| Coordinates: | 38.5428°N -85.6661°W |
| Elevation Ft: | 673 |
| Postal Code Type: | ZIP code |
| Postal Code: | 47163 |
| Blank Name: | FIPS code |
| Blank Info: | 18-57222[1] |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2830332 |
Otisco is an unincorporated community in Charlestown Township, Clark County, Indiana.
Otisco was laid out in 1854 when the railroad was extended to that point.[2] According to one source, the name might be borrowed from New York's Otisco Lake.[3]
The Otisco post office was established in 1870.[4]
Otisco is located along Indiana State Road 3 in the northern corner of Charlestown Township. The northern fringe of the town extends into neighboring Oregon Township.