Otilonium bromide explained

Otilonium bromide, sold under the trade name Spasmomen among others, is an antimuscarinic and calcium channel blocker used to relieve spasmodic pain of the gut, especially in irritable bowel syndrome.[1] This means it works in the gut themselves, by relaxing the small muscles of the intestines, which results in relieving cramps and therefore reduces pain.

Medical uses

A pooled analysis of three clinical trials suggest that otilonium is more effective than placebo for the treatment of irritable bowel syndrome.[2]

Pharmacology

Otilinium binds to both muscarinic receptors and tachykinin NK2 receptors.[3] It has been shown to inhibit L-type and T-type calcium channels, actions which may contribute to or determine its effects in the gut.[4] [5]

When taken orally, very little of the drug is absorbed into the rest of the body,[6] which means that most of its actions remain confined to the gastrointestinal system.

Notes and References

  1. Web site: https://web.archive.org/web/20160304071357/http://www.grupounipharm.com/sites/default/files/DISMOX+Inserto+CORREGIDO+2011.+Ingl%C3%A9s.pdf. Dismox. 4 March 2016.
  2. Clavé P, Tack J . Efficacy of otilonium bromide in irritable bowel syndrome: a pooled analysis . Therapeutic Advances in Gastroenterology . 10 . 3 . 311–322 . March 2017 . 28246548 . 5305018 . 10.1177/1756283X16681708 .
  3. Evangelista S . Otilonium bromide: a selective spasmolytic for the gastrointestinal tract . The Journal of International Medical Research . 27 . 5 . 207–22 . 1999 . 10689627 . 10.1177/030006059902700501 . free .
  4. Martin MT, Hove-Madsen L, Jimenez M . Otilonium bromide inhibits muscle contractions via L-type calcium channels in the rat colon . Neurogastroenterology and Motility . 16 . 2 . 175–83 . April 2004 . 15086871 . 10.1111/j.1365-2982.2004.00518.x . 7315438 .
  5. Strege PR, Sha L, Beyder A, Bernard CE, Perez-Reyes E, Evangelista S, Gibbons SJ, Szurszewski JH, Farrugia G . 6 . T-type Ca(2+) channel modulation by otilonium bromide . American Journal of Physiology. Gastrointestinal and Liver Physiology . 298 . 5 . G706-13 . May 2010 . 20203058 . 2867415 . 10.1152/ajpgi.00437.2009 .
  6. Shin BS, Kim JJ, Kim J, Hu SK, Kim HJ, Hong SH, Kim HK, Lee HS, Yoo SD . 6 . Oral bioavailability and enterohepatic recirculation of otilonium bromide in rats . Archives of Pharmacal Research . 31 . 1 . 117–24 . January 2008 . 18277617 . 10.1007/s12272-008-1129-2 . 25727036 .

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