Osoresnontrine Explained

Legal Status:	Investigational
Cas Number:	1189767-28-9
Pubchem:	135908617
Synonyms:	BI-409306
Iupac Name:	1-(Oxan-4-yl)-6-(pyridin-2-ylmethyl)-5H-pyrazolo[3,4-''d'']pyrimidin-4-one
C:	16
H:	17
N:	5
O:	2

Osoresnontrine (BI-409306) is a phosphodiesterase 9 inhibitor in development for schizophrenia,^[1] attenuated psychosis syndrome,^[2] and Alzheimer's disease.^[3] A preclinical study suggested that it increases memory in rodents.^[4]

Notes and References

1. Brown . David . Nakagome . Kazuyuki . Cordes . Joachim . Brenner . Ronald . Gründer . Gerhard . Keefe . Richard S E . Riesenberg . Robert . Walling . David P . Daniels . Kristen . Wang . Lara . McGinniss . Jennifer . Sand . Michael . Evaluation of the Efficacy, Safety, and Tolerability of BI 409306, a Novel Phosphodiesterase 9 Inhibitor, in Cognitive Impairment in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial . Schizophrenia Bulletin . 7 March 2019 . 45 . 2 . 350–359 . 10.1093/schbul/sby049 . free . 6403090 .
2. Keefe . Richard S. E. . Woods . Scott W. . Cannon . Tyrone D. . Ruhrmann . Stephan . Mathalon . Daniel H. . McGuire . Philip . Rosenbrock . Holger . Daniels . Kristen . Cotton . Daniel . Roy . Dooti . Pollentier . Stephane . Sand . Michael . A randomized Phase II trial evaluating efficacy, safety, and tolerability of oral BI 409306 in attenuated psychosis syndrome: Design and rationale . Early Intervention in Psychiatry . October 2021 . 15 . 5 . 1315–1325 . 10.1111/eip.13083 . en . 1751-7885. free . 8451588 .
3. Frölich . Lutz . Wunderlich . Glen . Thamer . Claus . Roehrle . Michael . Garcia . Miguel . Dubois . Bruno . Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in patients with prodromal and mild Alzheimer’s disease . Alzheimer's Research & Therapy . December 2019 . 11 . 1 . 10.1186/s13195-019-0467-2. free . 6371616 .
4. Rosenbrock . Holger . Giovannini . Riccardo . Schänzle . Gerhard . Koros . Eliza . Runge . Frank . Fuchs . Holger . Marti . Anelise . Reymann . Klaus G. . Schröder . Ulrich H. . Fedele . Ernesto . Dorner-Ciossek . Cornelia . The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents . Journal of Pharmacology and Experimental Therapeutics . 1 December 2019 . 371 . 3 . 633–641 . 10.1124/jpet.119.260059 . en . 0022-3565. free .