| Osman Hussein | |
| Office: | Acting Prime Minister of Sudan |
| Term Start: | 19 January 2022 |
| President: | Transitional Sovereignty Council |
| Predecessor: | Abdalla Hamdok |
| Office1: | General Secretary of the Prime Minister's Office |
| Term Start1: | 13 March 2019 |
| Term End1: | 19 January 2022 |
| President1: | Omar al-Bashir Ahmed Awad Ibn Auf Abdel Fattah al-Burhan |
| Primeminister1: | Mohamed Tahir Ayala Abdalla Hamdok |
| Birth Place: | Sudan |
| Party: | National Congress (until 2019) |
| Native Name Lang: | ar |
Osman Hussein (born 1951) is a Sudanese politician who has served as acting prime minister of Sudan since 19 January 2022, following the resignation of Abdalla Hamdok on 2 January 2022.[1] [2] He was the general secretary of the office of Prime Minister of the government of Sudan from 13 March 2019 until 19 January 2022.[3]