| Birth Date: | 28 February 1930 |
| Birth Place: | Alexandria, Egypt |
| Sport: | Greco-Roman wrestling |
| Show-Medals: | yes |
Muhammad Osman El-Sayed (Arabic: محمد عثمان السيد; 28 February 1930 - 21 April 2013) was a flyweight Greco-Roman wrestler from Egypt who won a silver medal at the 1960 Olympics.