| Osilo | |
| Official Name: | Comune di Osilo |
| Native Name: | Ósile |
| Pushpin Map: | Italy Sardinia |
| Coordinates: | 40.7333°N 48°W |
| Region: | Sardinia |
| Province: | Sassari (SS) |
| Frazioni: | Santa Vittoria, San Lorenzo |
| Mayor: | Giovanni Manca |
| Area Total Km2: | 98.3 |
| Population Total: | 3317 |
| Population As Of: | 31 December 2008[1] |
| Population Demonym: | Osilesi |
| Elevation M: | 672 |
| Postal Code: | 07033 |
| Area Code: | 079 |
Osilo (Sardinian: Ósile) is a comune (municipality) in the Province of Sassari in the Italian region Sardinia, located about 170km (110miles) north of Cagliari and about 10km (10miles) east of Sassari. It is part of the Anglona traditional region. The municipality of Osilo contains the frazioni (subdivisions, mainly villages and hamlets) Santa Vittoria and San Lorenzo.
Osilo borders the following municipalities: Cargeghe, Codrongianos, Muros, Nulvi, Ploaghe, Sassari, Sennori, Tergu.
Economy is mostly based on agriculture and animal husbandry, especially of sheep, which include about 250 dairy companies. It is the production center of the Osilo pecorino cheese. Sights include a castle and several churches.