| Oscar Lofton | |
| Birth Date: | 21 April 1938 |
| Birth Place: | McCall Creek, Mississippi, U.S. |
| Player Sport1: | Football |
| Player Years2: | 1957–1959 |
| Player Team2: | Southeastern Louisiana |
| Player Years3: | 1960 |
| Player Team3: | Boston Patriots |
| Player Sport4: | Basketball |
| Player Years5: | 1957–1959 |
| Player Team5: | Southeastern Louisiana |
| Player Positions: | End (football) |
| Coach Years1: | 1962–1966 |
| Coach Team1: | Holy Cross (assistant) |
| Coach Years2: | 1973–1978 |
| Coach Team2: | Tulane (assistant) |
| Coach Years3: | 1980–1985 |
| Coach Team3: | Southeastern Louisiana |
| Overall Record: | 30–34–1 |
Oscar W. Lofton (born April 2, 1938) is a former American football player and coach. He served as the head football coach at Southeastern Louisiana University from 1980 to 1985, compiling a record of 30–34–1.
Lofton played end for the Boston Patriots of the American Football League (AFL) in 1960. He scored the second touchdown in franchise history on a 60-yard pass play. He was drafted for military service and missed the 1961 and 1962 seasons. He returned to play for the Patriots but suffered a hamstring injury in training camp and never played another snap in pro football.
Lofton was the 11th head football coach at Southeastern Louisiana University in Hammond, Louisiana and he held that position for six seasons, from 1980 until 1985. His coaching record at Southeastern Louisiana was 30–34–1. Southeastern Louisiana discontinued its football program after the conclusion of the 1985 season, but reinstated the program in 2003 under head coach Hal Mumme.