Orthogonal signal correction explained

Orthogonal Signal Correction (OSC) is a spectral preprocessing technique that removes variation from a data matrix X that is orthogonal to the response matrix Y. OSC was introduced by researchers at the University of Umea in 1998 and has since found applications in domains including metabolomics.^{[1] [2] [3] [4]}

Notes and References

1. Mao H, Wang H, Wang B, etal. Systemic metabolic changes of traumatic critically ill patients revealed by an NMR-based metabonomic approach . J. Proteome Res. . 8 . 12 . 5423–30 . 2009. 19835422 . 10.1021/pr900576y .
2. Tzovaras VT, Psychogios NG, Kostara CE, Bairaktari ET, Elisaf MS . Evaluation of the proximal tubular function in individuals with primary renal hypouricemia: an NMR-based metabonomic study . NMR Biomed . 22 . 10 . 1072–83 . 2009. 19593759 . 10.1002/nbm.1415 .
3. Gu H, Pan Z, Xi B, etal. 1H NMR metabolomics study of age profiling in children . NMR Biomed . 22 . 8 . 826–33 . 2009 . 19441074 . 10.1002/nbm.1395 . 4009993.
4. Brindle JT, Nicholson JK, Schofield PM, Grainger DJ, Holmes E . Application of chemometrics to 1H NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension . Analyst . 128 . 1 . 32–6 . 2003 . 12572799 . 10.1039/b209155k. 2003Ana...128...32B .