Ortho-DOT, or 4,5-dimethoxy-2-methylthioamphetamine, is a lesser-known psychedelic drug. Ortho-DOT was first synthesized by Alexander Shulgin. In his book PiHKAL (Phenethylamines i Have Known And Loved), neither the dosage nor the duration are known. Ortho-DOT produces few to no effects.[1] Very little data exists about the pharmacological properties, metabolism, and toxicity of Ortho-DOT.