Ornatin Explained

Symbol:	Ornatin
Ornatin
Pfam:	PF02088
Interpro:	IPR002463

In molecular biology, ornatin is a potent glycoprotein IIb-IIIa (GP IIb-IIIa) antagonist and platelet aggregation inhibitor isolated from Placobdella ornata (Turtle leech).^[1] The protein is 41-52 amino acids in length and contains the RGD recognition motif common in adhesion proteins, and 6 conserved cysteine residues. These form three disulphide bonds, which are required for activity.^[2] The sequences of ornatin B, C, D and E are highly similar, while A2 and A3 are less similar, lacking the N-terminal 9 residues. Ornatins share ~40% identity with decorsin, a GP IIb-IIIa antagonist isolated from the leech (Macrobdella decora).^[1]

Notes and References

1. Mazur P, Henzel WJ, Seymour JL, Lazarus RA . Ornatins: potent glycoprotein IIb-IIIa antagonists and platelet aggregation inhibitors from the leech Placobdella ornata . Eur. J. Biochem. . 202 . 3 . 1073–82 . December 1991 . 1765068 . 10.1111/j.1432-1033.1991.tb16472.x. free .
2. Mazur P, Dennis MS, Seymour JL, Lazarus RA . Expression, purification, and characterization of recombinant ornatin E, a potent glycoprotein IIb-IIIa antagonist. . Protein Expr Purif . 1993 . 4 . 4 . 282–9 . 8374297 . 10.1006/prep.1993.1036 .