Orlando D. Schärer Explained

Orlando D. Schärer
Fields:Chemical biology, molecular biology, cell biology
Workplaces:Center for Genomic Integrity,
Institute for Basic Science
UNIST
Stony Brook University
University of Zürich
Alma Mater:Harvard University, ETH Zürich
Thesis Title:A chemical approach toward understanding base excision DNA repair enzymes
Thesis Year:1996
Academic Advisors:Duilio Arigoni, Roland Kanaar, Jan Hoeijmakers
Doctoral Advisors:Gregory L. Verdine
Website:IBS Center for Genomic Integrity Chemical & Cancer Biology Branch

Orlando David Schärer is a Swiss chemist and biologist researching DNA repair, genomic integrity, and cancer biology.[1] Schärer has taught biology, chemistry and pharmacology at various university levels on three continents. He is a distinguished professor at the Ulsan National Institute of Science and Technology (UNIST) and an associate director of the IBS Center for Genomic Integrity located in Ulsan, South Korea. He leads the three interdisciplinary research teams in the Chemical & Cancer Biology Branch of the center and specifically heads the Cancer Therapeutics Mechanisms Section.[2]

Education

Majoring in chemistry at ETH Zürich in Switzerland, Schärer received his Diplom (MSc) in 1991 after studying under Professor Duilio Arigoni. He then attended a chemistry PhD program at Harvard and graduated in 1996. As a graduate student in the laboratory of Professor Gregory L. Verdine, Schärer developed chemical approaches to study the DNA glycosylases in base excision repair.[3] [4]

Career

Schärer started his career in 1996, as a Human Frontier Science Program postdoctoral fellow in the Department of Cell Biology and Genetics of Erasmus University Rotterdam under Professors Roland Kanaar and Jan Hoeijmakers.[5] During this fellowship, he researched biochemical and genetic aspects of homologous recombination in mammals.[6] Starting in 1999, he was an independent group leader and START Fellow (Swiss Science Foundation Research Professor) in the Institute of Molecular Cancer Research at the University of Zürich.[6] That marked the start of the Schärer lab - researching chemical, biochemical and cell biological approaches to research nucleotide excision repair, interstrand crosslink repair and how DNA repair pathways impact cancer chemotherapy.[7] The last four years of his time in Zürich, he taught biological chemistry as a lecturer at ETH Zürich.

From 2005, he continued his research as a tenured associate professor at Stony Brook in the Departments of Pharmacological Sciences and Chemistry and as a member of the Institute for Chemical Biology and Drug Design.[8] [9] During a sabbatical leave in 2011, he was a visiting scientist at the Institute of Molecular Cancer Research in the University of Zürich. Returning from Switzerland, he became a full professor.

In 2017, he became a distinguished professor and the associate director of the IBS Center for Genomic Integrity in UNIST, headed by Myung Kyungjae.[10] [11] Located in Ulsan City, Republic of Korea, the new laboratory is divided into three sections; DNA Damage Repair, Molecular Cancer Research, and Cancer Therapeutics Mechanisms.[12]

The Schärer Laboratory is best known for the development of syntheses of DNA interstrand crosslinks[13] [14] and other DNA lesions and mechanistic studies of human nucleotide excision repair and interstrand crosslink repair and structure-specific nucleases, such as ERCC1-XPF[15] [16] and XPG.[17] [18]

Honors and awards

See also

External links

Notes and References

  1. Web site: The synergy between IBS and UNIST propels research forward . . 3 February 2021 . Institute for Basic Science . 4 March 2021 .
  2. Web site: Research Groups . . Schärer Laboratory . 26 July 2019 .
  3. Schärer . Orlando D. . Ortholand . Jean-Yves . Ganesan . A. . Ezaz-Nikpay . Khosro . Verdine . Gregory L. . Gregory L. Verdine . June 1995 . Specific binding of the DNA repair enzyme AlkA to a pyrrolidine-based inhibitor . Journal of the American Chemical Society . 117 . 24 . 6623–6624 . American Chemical Society . 10.1021/ja00129a039 .
  4. Labahn . Jörg . Schärer . Orlando D. . Long . Alexander . Ezaz-Nikpay . Khosro . Verdine . Gregory L. . Gregory L. Verdine . Ellenberger . Tom E. . 26 July 1996 . Structural basis for the excision repair of alkylation-damaged DNA . Cell . 86 . 2 . 321–329 . 10.1016/S0092-8674(00)80103-8 . Cell Press . 8706136 . 15333632 . free .
  5. Web site: People: Branch Director . . Scharer Laboratory . 5 July 2019 . ...postdoctoral studies at Erasmus University, Netherlands (Advisors: Profs. Roland Kanaar and Jan Hoeijmakers)....
  6. Gillet . Ludovic CJ . Schärer . Orlando D. . 27 December 2005 . Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair . Chemical Reviews . American Chemical Society . 106 . 2 . 253–276 . 10.1021/cr040483f . 16464005 .
  7. Web site: Orlando D. Schärer . . . 21 June 2019 .
  8. Web site: Faculty: ORLANDO D. SCHÄRER, PROFESSOR . . . 21 June 2019 .
  9. Web site: Faculty / Research: ORLANDO D. SCHÄRER, PHD . . Department of Pharmacological Sciences . Stony Brook University School of Medicine . 21 June 2019 .
  10. Web site: Orlando D., Schaerer 올란도 . . School of Life Sciences . Ulsan National Institute of Science and Technology . 5 July 2019 .
  11. Web site: Associate Director . . Center for Genomic Integrity . Institute for Basic Science . 5 July 2019 .
  12. Web site: Research Groups . . Scharer Laboratory . 5 July 2019 .
  13. Angelov . Todor . Guainazzi . Angelo . Schärer . Orlando D. . 8 January 2009 . Generation of DNA Interstrand Cross-Links by Post-Synthetic Reductive Amination . Organic Letters . 11 . 3 . American Chemical Society . 661–664 . 10.1021/ol802719a . 19132933 . 2635425 .
  14. Mukherjee . Shivam . Guainazzi . Angelo . Schärer . Orlando D. . 17 June 2014 . Nucleic Acids Research . 2014 . 42 . 11 . 7429–7435 . 10.1093/nar/gku328 . 24782532 . 4066762 .
  15. Enzlin . Jacqueline H. . Schärer . Orlando D. . 15 April 2002 . The active site of the DNA repair endonuclease XPF–ERCC1 forms a highly conserved nuclease motif . EMBO J . 21 . 8 . 2045–2053 . 10.1093/emboj/21.8.2045 . 11953324 . 125967 .
  16. Orelli . Barbara . McClendon . T. Brooke . Tsodikov . Oleg V. . Ellenberger . Tom . Niedernhofer . Laura J. . Schärer . Orlando D. . 5 February 2010 . The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways . Journal of Biological Chemistry . 285 . 6 . 3705–3712 . 10.1074/jbc.M109.067538 . free . 19940136 . 2823511 .
  17. Fagbemi . Adebanke F. . Orellia . Barbara . Schärer . Orlando D. . 15 July 2011 . Regulation of endonuclease activity in human nucleotide excision repair . DNA Repair . 10 . 7 . 722–729 . 10.1016/j.dnarep.2011.04.022 . 21592868 . 3139800 .
  18. Staresincic . Lidija . Fagbemi . Adebanke F. . Enzlin . Jacqueline H. . Gourdin . Audrey M. . Wijgers . Nils . Dunand-Sauthier . Isabelle . Giglia-Mari . Giuseppina . Clarkson . Stuart G. . Vermeulen . Wim . Schärer . Orlando D. . 22 April 2009 . Coordination of dual incision and repair synthesis in human nucleotide excision repair . EMBO J . 28 . 8 . 1111–1120 . 10.1038/emboj.2009.49 . 19279666 . 2683701 .
  19. Web site: Senior Research Excellence Award Recipients . . Renaissance School of Medicine . Stony Brook Medicine . 5 July 2019 .
  20. Web site: Controlling Traffic on the Streets and at the Crossroads of DNA Repair Pathways . . 8–13 February 2015 . Gordon Research Conference: Mammalian DNA Repair . 26 July 2019 . Chairs Orlando D. Schärer.
  21. Web site: Awards . . Stony Brook University . 5 July 2019 .
  22. Web site: Awards: Faculty Development Award . . Stony Brook University . 5 July 2019 .
  23. Web site: Awardees . . . 30 November 2023 .
  24. Book: . 2004 . EMBO EMBC Annual Report 2004 . English . European Molecular Biology Organization . 113 . 5 July 2019 .
  25. Book: . 2006 . EMBO EMBC Annual Report 2006: Promoting Excellence in the Molecular Life Sciences . English . European Molecular Biology Organization . 115 . 5 July 2019 .

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