| State: | OR |
| Type: | OR |
| Route: | 380 |
| Map Custom: | yes |
| Map Notes: | Route 380 highlighted in red |
| Length Mi: | 55.49 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Direction A: | West |
| Terminus A: | in Prineville |
| Direction B: | East |
| Terminus B: | Beaver Creek Bridge in Paulina |
| Established: | 2002 |
| Previous Type: | OR |
| Previous Route: | 370 |
| Next Type: | US |
| Next Route: | 395 |
Oregon Route 380 (OR 380) is an Oregon state highway running from Prineville to Paulina. OR 380 is known as the Paulina Highway No. 380 (see Oregon highways and routes). It is 55.49miles long and runs east - west, entirely within Crook County. OR 380 was assigned to the Paulina Highway in 2002.
OR 380 begins at an intersection with U.S. Route 26 (US 26) at Prineville and heads east through Post to Paulina, where it ends at the Beaver Creek Bridge.
OR 380 was established in 2002 as part of Oregon's project to assign route numbers to highways that previously were not assigned.