| State: | OR |
| Type: | OR |
| Route: | 350 |
| Map Custom: | yes |
| Map Notes: | Route 350 highlighted in red |
| Length Mi: | 29.36 |
| Length Round: | 2 |
| Direction A: | West |
| Terminus A: | OR 82 and OR 351 in Joseph |
| Direction B: | East |
| Terminus B: | Upper Imnaha Road and Grizzly Ridge Road in Imnaha |
| Established: | 2003 |
| Previous Type: | OR |
| Previous Route: | 339 |
| Next Type: | OR |
| Next Route: | 351 |
Oregon Route 350 is an Oregon state highway running from Joseph to Imnaha. OR 350 is known as the Little Sheep Creek Highway No. 350 (see Oregon highways and routes). It is 29.36miles long and runs east - west, entirely within Wallowa County.
OR 350 was established in 2003 as part of Oregon's project to assign route numbers to highways that previously were not assigned, and, as of July 2022, ODOT is posting route shields.
OR 350 begins at an intersection with OR 82 and OR 351 in Joseph and heads east and northeast to Imnaha, where it ends at the intersection of Upper Imnaha Road and Grizzly Ridge Road.
It is part of Hells Canyon Scenic Byway.
OR 350 was assigned to the Little Sheep Creek Highway in 2003.