| State: | OR |
| Type: | OR |
| Route: | 281 |
| Map Custom: | yes |
| Map Notes: | Route 281 highlighted in red |
| Length Mi: | 19.01 |
| Direction A: | South |
| Terminus A: | in Mount Hood |
| Junction: | near Hood River |
| Direction B: | North |
| Terminus B: | in Hood River |
| Established: | 2002 |
| Previous Type: | OR |
| Previous Route: | 273 |
| Next Type: | OR |
| Next Route: | 282 |
Oregon Route 281 is an Oregon state highway running from Hood River to the community of Mount Hood. OR 281 is known as the Hood River Highway No. 281 (see Oregon highways and routes). It is 19.01miles long and runs north–south, entirely within Hood River County.
OR 281 was established in 2002 as part of Oregon's project to assign route numbers to highways that previously were not assigned.
OR 281 begins at an intersection with US 30 and OR 35 at Hood River and heads south, intersecting OR 282 five miles (8 km) south of Hood River. OR 281 continues south through Winans, Dee, and Trout Creek to Parkdale. At Parkdale, OR 281 turns northeast for two miles (3 km) to the community of Mount Hood, where it ends at an intersection with OR 35. OR 281 is also known as Dee Highway as residents that live along the highway have the name as part of their mailing address.
OR 281 was assigned to the Hood River Highway in 2002.