| Opequon, Virginia | |
| Settlement Type: | Unincorporated community |
| Pushpin Map: | Virginia#USA |
| Pushpin Label: | Opequon |
| Pushpin Label Position: | bottom |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Virginia |
| Subdivision Type2: | County |
| Subdivision Name2: | Frederick |
| Unit Pref: | Imperial |
| Population As Of: | 2000 |
| Population Density Km2: | auto |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Coordinates: | 39.1572°N -78.2467°W |
| Postal Code Type: | ZIP codes |
| Blank Name: | FIPS code |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 1499825 |
Opequon is an unincorporated community along Opequon Creek in Frederick County, northwestern Virginia. Also known as Kernstown, the community center is served by Cedar Creek Grade (VA 622) at Miller Road (VA 620).
The community of Opequon was designated as a National Historic District in 2002. Opequon School, which operated from 1884 to 1934, still stands on Glass Spring Road in town. Also on this road is the Second Opequon Presbyterian Church.
The Opequon Quaker Camp (OQC) is a sleep-away, coed summer camp for children ages nine to fourteen; it is located just north of Winchester, Virginia. It as a part of the Baltimore Yearly Meeting Camps. While it is a Quaker camp, it is open to non-Quaker children and has attracted campers from other regions and countries. Camping trips and activities feature canoeing, backpacking on the Appalachian Trail, rock climbing, and chores.