Opelconazole Explained

Width:	250px
Legal Status:	Investigational
Cas Number:	1931946-73-4
Pubchem:	121383526
Unii:	45LU8Q6ASU
Synonyms:	PC-945
Iupac Name:	4-[4-[4-[[(3''R'',5''R'')-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]-3-methylphenyl]piperazin-1-yl]-N-(4-fluorophenyl)benzamide
C:	38
H:	37
F:	3
N:	6
O:	3

Opelconazole (PC-945) is an experimental antifungal drug and the first triazole delivered via inhalation.^{[1] [2] [3]} The drug is in Phase III and Phase II trials as of 2023.^[4]

Notes and References

1. Wiederhold . Nathan P. . Pharmacodynamics, Mechanisms of Action and Resistance, and Spectrum of Activity of New Antifungal Agents . Journal of Fungi . August 2022 . 8 . 8 . 857 . 10.3390/jof8080857 . en . 2309-608X. free . 36012845 . 9410397 .
2. Neoh . Chin Fen . Jeong . Wirawan . Kong . David CM . Slavin . Monica A . The antifungal pipeline for invasive fungal diseases: what does the future hold? . Expert Review of Anti-infective Therapy . 3 June 2023 . 21 . 6 . 577–594 . 10.1080/14787210.2023.2203383. 37057677 . 258135111 .
3. Ito . Kazuhiro . Inhaled antifungal therapy: benefits, challenges, and clinical applications . Expert Opinion on Drug Delivery . 2022 . 19 . 7 . 755–769 . 10.1080/17425247.2022.2084530. free . 35634895 .
4. Web site: Pulmocide Announces New Clinical Data Confirming Low Potential for Drug-Drug Interactions with Inhaled Opelconazole . BioSpace . 4 November 2023.