Ononin Explained

Ononin is an isoflavone glycoside, the 7-O-β-D-glucopyranoside of formononetin,^[1] which in turn is the 4'-O-methoxy derivative of the parent isoflavone daidzein.

Natural sources

Ononin is a major isoflavone ^[2] found in a number of plants and herbs like soybean^[3] and Glycyrrhiza uralensis.^[4]

Pharmacokinetics

Intestinal bacterial metabolic pathways may include demethylation and deglycosylation.^[5] It follows that formation of formononetin and/or daidzein is possible.

Pharmacodynamics

An in vitro anti-inflammatory effect on lipopolysaccharide (LPS)-induced inflammation has been demonstrated in one study.^[6]

Notes and References

1. Book: Chinese Materia Medica: Chemistry, Pharmacology and Applications . You-Ping Zhu . 28 May 1998 . 622 . CRC Press . 9057022850.
2. 10.1016/j.molimm.2017.01.007 . Anti-inflammatory effects of ononin on lipopolysaccharide-stimulated RAW 264.7 cells . Molecular Immunology . 83 . 46–51 . 2017 . Dong . Lin . Yin . Lei . Zhang . Yuanbin . Fu . Xueyan . Lu . Jincai . 28095349 . 3443736 .
3. Phytochemistry . 2 . 9 . 1983 . 1921–1923 . Isoflavone glucoside stress metabolites of soybean leaves . Stanley F. Osman . William F. Fett . 10.1016/0031-9422(83)80013-2 . 1983PChem..22.1921O .
4. Phytochemistry . 24 . 2 . 1985 . 339–341 . Flavonoid glycosides of the roots of Glycyrrhiza uralensis . Tsutomu Nakanishi . Akira Inada . Kazuko Kambayashia . Kaisuke Yonedaa . 10.1016/S0031-9422(00)83548-7. 1985PChem..24..339N .
5. 25322559 . Yao Xue Xue Bao . 2014 . 49 . 8 . 1162–1168 . The interaction between ononin and human intestinal bacteria . Chinese . Zhang W, Jiang S, Qian DW, Shang EX, Guan HL, Ren H, Zhu ZH, Duan JA.
6. 10.1016/j.molimm.2017.01.007. Anti-inflammatory effects of ononin on lipopolysaccharide-stimulated RAW 264.7 cells. Molecular Immunology. 83. 46–51. 2017. Dong. Lin. Yin. Lei. Zhang. Yuanbin. Fu. Xueyan. Lu. Jincai. 28095349. 3443736.