| One South Wacker | |
| Location: | 1 South Wacker Drive, Chicago, Illinois |
| Coordinates: | 41.8816°N -87.6362°W |
| Start Date: | 1979 |
| Completion Date: | 1982 |
| Building Type: | Office |
| Roof: | 550feet |
| Floor Count: | 40 |
| Floor Area: | 108138m2 |
| Architect: | Murphy/Jahn, Inc. Architects |
One South Wacker is a 550 ft (168 m) tall 40-floor skyscraper in Chicago, Illinois, United States, designed by Murphy/Jahn, Inc. Architects, and constructed from 1979 to 1982. The building is tied for the 72nd tallest building in Chicago.
The music video for "Burnin'" by Daft Punk was filmed at the tower.