Oncomodulin 2 Explained

Oncomodulin 2, also known as OCM2, is a human gene that is similar to oncomodulin.

Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin 2 is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors.^[1]

Further reading

• Pauls TL, Cox JA, Berchtold MW . The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings. . Biochim. Biophys. Acta . 1306 . 1 . 39–54 . 1996 . 8611623 . 10.1016/0167-4781(95)00221-9.
• Belkacemi L, Simoneau L, Lafond J . Calcium-binding proteins: distribution and implication in mammalian placenta. . Endocrine . 19 . 1 . 57–64 . 2003 . 12583602 . 10.1385/ENDO:19:1:57 . 28802052 .
• Ritzler JM, Sawhney R, Geurts van Kessel AH, etal . The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome. . Genomics . 12 . 3 . 567–72 . 1992 . 1559707 . 10.1016/0888-7543(92)90449-3 .
• Palmer EJ, MacManus JP, Mutus B . Inhibition of glutathione reductase by oncomodulin. . Arch. Biochem. Biophys. . 277 . 1 . 149–54 . 1990 . 2306116 . 10.1016/0003-9861(90)90563-E .
• Mutus B, Palmer EJ, MacManus JP . Disulfide-linked dimer of oncomodulin: comparison to calmodulin. . Biochemistry . 27 . 15 . 5615–22 . 1988 . 3179268 . 10.1021/bi00415a033 .
• Gillen MF, Banville D, Rutledge RG, etal . A complete complementary DNA for the oncodevelopmental calcium-binding protein, oncomodulin. . J. Biol. Chem. . 262 . 11 . 5308–12 . 1987 . 10.1016/S0021-9258(18)61189-5 . 3558395 . free .
• MacManus JP, Brewer LM, Whitfield JF . The widely-distributed tumour protein, oncomodulin, is a normal constituent of human and rodent placentas. . Cancer Lett. . 27 . 2 . 145–51 . 1985 . 4005827 . 10.1016/0304-3835(85)90103-X .
• Blum JK, Berchtold MW . Calmodulin-like effect of oncomodulin on cell proliferation. . J. Cell. Physiol. . 160 . 3 . 455–62 . 1994 . 8077283 . 10.1002/jcp.1041600308 . 25079233 .
• Föhr UG, Weber BR, Müntener M, etal . Human alpha and beta parvalbumins. Structure and tissue-specific expression. . Eur. J. Biochem. . 215 . 3 . 719–27 . 1993 . 8354278 . 10.1111/j.1432-1033.1993.tb18084.x . free .
• Sakaguchi N, Henzl MT, Thalmann I, etal . Oncomodulin is expressed exclusively by outer hair cells in the organ of Corti. . J. Histochem. Cytochem. . 46 . 1 . 29–40 . 2000 . 9405492 . 10.1177/002215549804600105 . free .
• Toward a complete human genome sequence. . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .
• Harrington JJ, Sherf B, Rundlett S, etal . Creation of genome-wide protein expression libraries using random activation of gene expression. . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . 25064683 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hillier LW, Fulton RS, Fulton LA, etal . The DNA sequence of human chromosome 7 . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Babini E, Bertini I, Capozzi F, etal . Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs . Biochemistry . 43 . 51 . 16076–85 . 2005 . 15610002 . 10.1021/bi048388o .

Notes and References

1. Web site: Entrez Gene: OCM oncomodulin.