OmpA domain explained

Symbol:	OmpA
OmpA family
Pfam:	PF00691
Interpro:	IPR006665
Prosite:	PDOC00819
Scop:	1r1m
Tcdb:	1.B.6

In molecular biology, the OmpA domain is a conserved protein domain with a beta/alpha/beta/alpha-beta(2) structure found in the C-terminal region of many Gram-negative bacterial outer membrane proteins, such as porin-like integral membrane proteins (such as ompA), small lipid-anchored proteins (such as pal), and MotB proton channels.^{[1] [2] [3] [4]} The N-terminal half of these proteins is variable although some of the proteins in this group have the OmpA-like transmembrane domain at the N terminus. OmpA from Escherichia coli is required for pathogenesis, and can interact with host receptor molecules.^[5] MotB (and MotA) serve two functions in E. coli, the MotA(4)-MotB(2) complex attaches to the cell wall via MotB to form the stator of the flagellar motor, and the MotA-MotB complex couples the flow of ions across the cell membrane to movement of the rotor.^[4]

See also

• OmpA-like transmembrane domain

Notes and References

1. Bouveret E, Benedetti H, Rigal A, Loret E, Lazdunski C . In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions . J. Bacteriol. . 181 . 20 . 6306–11 . October 1999 . 10515919 . 103764 . 10.1128/JB.181.20.6306-6311.1999.
2. De Mot R, Proost P, Van Damme J, Vanderleyden J . Homology of the root adhesin of Pseudomonas fluorescens OE 28.3 with porin F of P. aeruginosa and P. syringae . Mol. Gen. Genet. . 231 . 3 . 489–93 . February 1992 . 1538702 . 10.1007/BF00292721 . 7518948 .
3. Freudl R, Klose M, Henning U . Export and sorting of the Escherichia coli outer membrane protein OmpA . J. Bioenerg. Biomembr. . 22 . 3 . 441–9 . June 1990 . 2202726 . 10.1007/BF00763176. 22623025 .
4. Hosking ER, Vogt C, Bakker EP, Manson MD . The Escherichia coli MotAB proton channel unplugged . J. Mol. Biol. . 364 . 5 . 921–37 . December 2006 . 17052729 . 10.1016/j.jmb.2006.09.035 .
5. Selvaraj SK, Periandythevar P, Prasadarao NV . Outer membrane protein A of Escherichia coli K1 selectively enhances the expression of intercellular adhesion molecule-1 in brain microvascular endothelial cells . Microbes Infect. . 9 . 5 . 547–57 . April 2007 . 17368067 . 1993839 . 10.1016/j.micinf.2007.01.020 .