| Honorific-Prefix: | Ambassador |
| Ombeni Sefue | |
| Office: | Chief Secretary to the President |
| Term Start: | 31 December 2011 |
| Term End: | 6 March 2016 |
| President: | John Pombe Magufuli |
| Predecessor: | Phillemon Luhanjo |
| Successor: | John William Kijazi |
| Office2: | Permanent Representative of Tanzania to the United Nations |
| Term Start2: | 31 August 2010 |
| Term End2: | December 2011 |
| Predecessor2: | Augustine Mahiga |
| Successor2: | Tuvako Manongi |
| Office3: | Tanzanian Ambassador to the United States |
| Term Start3: | 15 June 2007 |
| Term End3: | 14 August 2010 |
| President3: | Jakaya Kikwete |
| Office4: | Tanzanian High Commissioner to Canada |
| Term Start4: | October 2005 |
| Term End4: | June 2007 |
| Office5: | Personal Assistant to the President |
| Term Start5: | May 1993 |
| Term End5: | September 2005 |
| Birth Date: | 26 August 1954 |
| Birth Place: | Same District, Tanganyika |
| Nationality: | Tanzanian |
| Spouse: | Anita |
| Children: | 2 |
| Profession: | Diplomat |
Ombeni Yohana Sefue (born 26 August 1954) is a former Tanzanian diplomat. He was appointed as the Chief Secretary to the President of Tanzania on 31 December 2011.[1] Previously he was the Permanent Representative of Tanzania to the United Nations.
Order of the United Republic of Tanzania (First Class), December 2012