Olorofim Explained

Legal Status:Investigational
Cas Number:1928707-56-5
Pubchem:91885568
Unii:T34SH2H9HI
Synonyms:F901318
Iupac Name:2-(1,5-Dimethyl-3-phenylpyrrol-2-yl)-N-[4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl]-2-oxoacetamide
C:28
H:27
F:1
N:6
O:2

Olorofim (F901318) is an experimental antifungal drug being developed for invasive mold infections.[1] [2] If approved it would be a first-in-class medication (for the orotomide class). In 2023, the FDA decided not to approve the drug and to request more data about the safety of the drug.[3] Olorofim does not inhibit growth of Candida species.[2]

Notes and References

  1. Neoh . Chin Fen . Jeong . Wirawan . Kong . David CM . Slavin . Monica A . The antifungal pipeline for invasive fungal diseases: what does the future hold? . Expert Review of Anti-infective Therapy . 2023 . 21 . 6 . 577–594 . 10.1080/14787210.2023.2203383. 37057677 . 258135111 .
  2. Wiederhold . Nathan P. . Review of the Novel Investigational Antifungal Olorofim . Journal of Fungi . 2020 . 6 . 3 . 122 . 10.3390/jof6030122 . 32751765 . 7557671 . 2309-608X . free .
  3. Web site: FDA Passes on Olorofim Despite Critical Need for Antifungals . Medscape . en.