ABC-type oligopeptide transporter explained

ABC-type oligopeptide transporter
Ec Number:	7.4.2.6
Go Code:	0015421

The ABC-type oligopeptide transporter or oligopeptide permease is an enzyme that catalyzes the chemical reaction

ATP + H₂O + oligopeptide(out)

\rightleftharpoons ADP + phosphate + oligopeptide(in)

The 3 substrates of this enzyme are ATP, H₂O, and oligopeptide, whereas its 3 products are ADP, phosphate, and oligopeptide.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (ABC-type, oligopeptide-importing).

References

• Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH . 1995 . Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases . Res. Microbiol. . 146 . 271 - 8 . 7569321 . 4 . 10.1016/0923-2508(96)81050-3. free .
• Saier MH Jr . 1998 . Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya . Adv. Microb. Physiol. . Advances in Microbial Physiology . 40 . 81 - 136 . 9889977 . 10.1016/S0065-2911(08)60130-7 . 9780120277407 .
• Griffiths JK . Sansom CE . The Transporter Factsbook, Academic Press, San Diego, 1998 .
• Pearce SR, Mimmack ML, Gallagher MP, Gileadi U, Hyde SC, Higgins CF . 1992 . Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium . Mol. Microbiol. . 6 . 47 - 57 . 1738314 . 10.1111/j.1365-2958.1992.tb00836.x . 1 . 1660114 .