| State: | OH |
| Type: | SR |
| Route: | 564 |
| Map: | OH 564 map.svg |
| Maint: | ODOT |
| Length Mi: | 13.48 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Established: | 1937 |
| Direction A: | West |
| Terminus A: | in Caldwell |
| Direction B: | East |
| Terminus B: | in Jefferson Township |
| Counties: | Noble |
| Previous Type: | OH 1960 |
| Previous Route: | 563 |
| Next Type: | SR |
| Next Route: | 565 |
State Route 564 (SR 564) is a 13.48adj=midNaNadj=mid state highway in Noble County, Ohio, USA. The signed east–west route, though physically more northwest–southeast, begins at SR 78 on the outskirts of Caldwell and ends at SR 145 in Jefferson Township.
The route begins at an intersection with SR 78 on the southeast corner of Caldwell. It immediately crosses Salt Run before curving to climb a small hill. After two switchback turns, SR 564 reaches the top of the hill and begins to slowly descend in elevation. Soon, the route follows a valley created by the Middle Fork Duck Creek and remains in this valley and occasionally crossing over the aforementioned stream. Just before the main Duck Creek, the route ends at SR 145 just outside the community of Harriettsville. The entire route is two lanes wide and is located within very rural areas punctuated occasionally with small houses.
SR 564 was designated a state highway around 1937.[2] [3] It has always followed the SR 78–SR 145 routing since its designation. The route north of the former SR 563 near Middleburg has always been asphalt-paved, the portion south of there was paved by 1958.[2] [4]