| State: | OH |
| Type: | SR |
| Route: | 255 |
| Length Mi: | 18.08 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Map: | OH 255 map.svg |
| Established: | 1935 |
| Direction A: | West |
| Terminus A: | near Woodsfield |
| Direction B: | East |
| Terminus B: | in Sardis |
| Counties: | Monroe |
| Previous Type: | SR |
| Previous Route: | 254 |
| Next Type: | SR |
| Next Route: | 256 |
State Route 255 (SR 255) is an east - west state route located in southeast Ohio. Nestled entirely inside the southeast quadrant of Monroe County, the western terminus of State Route 255 is at a T-intersection with State Route 800 approximately 3miles south of Woodsfield. Its eastern terminus is at State Route 7 in the hamlet of Sardis, which is situated along the banks of the Ohio River.
SR 255 was commissioned in 1935 on the same alignment as it currently occupies. Paving of the route between SR 800 and the Little Muskingum River was completed between 1957 and 1959. The rest of the route was paved by 1961.