Odontophrynus cultripes is a species of frog in the family Odontophrynidae. It is endemic to southeastern Brazil and known from Minas Gerais, Goiás, and São Paulo states. It is mostly found at altitudes higher than 800m (2,600feet) above sea level.
Males measure 50mm60mm and females 45mm70mm in snout–vent length. The snout is vertical in profile. The parotoid glands are large and ovoid. Dorsal ground colour is greyish green. The male advertisement call is composed of a single, multi-pulsed note.
Odontophrynus cultripes is a fossorial species that occurs in open areas, forest edges, and suburban gardens. It is an abundant species that breeds explosively in temporary pools, including man-made ones. Although not threatened, habitat loss caused by infrastructure development and agricultural activities can negatively impact the species.