| Odesa Secondary School No. 121 | |
| Principal: | Semeniuk Liudmyla Mykolaivna |
| Grades: | 1–11 |
| Streetaddress: | 1 Tolstoy Street |
| Province: | 65023 |
| Country: | Ukraine |
| Coordinates: | 46.4828°N 30.7294°W |
The 121st Secondary School or officially Comprehensive Secondary School No. 121 with Deep Learning of Foreign Languages of Prymorskyi Raion of Odesa Municipality (Ukrainian: Середня загальноосвітня школа І-ІІІ ступенів № 121 з поглибленим вивченням іноземних мов Приморського району м. Одеси) is an ordinary public school which provides compulsory and specialized education.
The school was opened in 1937 and is located near the Odesa Orthodox Cathedral. The school building was built on a standard project (based on designs by architect L.B. Belkin).
English at the school has had deeper learning since 1954. The basic language of training is Ukrainian.