Oculomucocutaneous syndrome explained

Specialty:ophthalmology

Oculomucocutaneous syndrome is characterized by keratoconjunctivitis sicca (dry eyes) and the resulting scarring, fibrosis, metaplasia, and shrinkage of the conjunctiva.[1] It is a drug side effect observed in practolol and eperisone. It is speculated that antibodies against drug metabolites cause the syndrome.[2]

Notes and References

  1. Wright. P. Untoward effects associated with practolol administration: oculomucocutaneous syndrome.. British Medical Journal. Mar 15, 1975. 1. 5958. 595–8. 1125623. 1672788. 10.1136/bmj.1.5958.595.
  2. Amos. HE. Lake, BG . Artis, J . Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome.. British Medical Journal. Feb 18, 1978. 1. 6110. 402–4. 146533. 1602979. 10.1136/bmj.1.6110.402.

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