POU2F1 explained

POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.^{[1] [2]}

Interactions

POU2F1 has been shown to interact with:

• EPRS,^[3]
• Glucocorticoid receptor,^{[4] [5] [6]}
• Glyceraldehyde 3-phosphate dehydrogenase,
• Host cell factor C1,^{[7] [8]}
• Ku80,^{[9] [10]}
• MNAT1^[11]
• NPAT,^[12]
• Nuclear receptor co-repressor 2,^[13]
• POU2AF1,^{[14] [15]}
• RELA,^[16]
• Retinoid X receptor alpha,^{[4] [17]}
• SNAPC4,^{[18] [19]}
• Sp1 transcription factor,^{[20] [21]} and
• TATA binding protein.^[22]

See also

• Octamer transcription factor

Further reading

• Hsieh CL, Sturm R, Herr W, Francke U . The gene for the ubiquitous octamer-binding protein Oct–1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1 . Genomics . 6 . 4 . 666–72 . 1990 . 2341156 . 10.1016/0888-7543(90)90502-L . free .
• Sturm RA, Das G, Herr W . The ubiquitous octamer-binding protein Oct–1 contains a POU domain with a homeo box subdomain . Genes Dev. . 2 . 12A . 1582–99 . 1989 . 2905684 . 10.1101/gad.2.12a.1582 . free .
• Nakshatri H, Nakshatri P, Currie RA . Interaction of Oct–1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter . J. Biol. Chem. . 270 . 33 . 19613–23 . 1995 . 7642649 . 10.1074/jbc.270.33.19613 . free . 1805/18867 . free .
• Cox M, van Tilborg PJ, de Laat W, Boelens R, van Leeuwen HC, van der Vliet PC, Kaptein R . Solution structure of the Oct–1 POU homeodomain determined by NMR and restrained molecular dynamics . J. Biomol. NMR . 6 . 1 . 23–32 . 1995 . 7663141 . 10.1007/BF00417488 . 26063646 .
• Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H . In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor . J. Virol. . 67 . 10 . 6224–33 . 1993 . 10.1128/JVI.67.10.6224-6233.1993 . 7690421 . 238044 .
• Zwilling S, König H, Wirth T . High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors . EMBO J. . 14 . 6 . 1198–208 . 1995 . 7720710 . 398197 . 10.1002/j.1460-2075.1995.tb07103.x.
• Sturm RA, Eyre HJ, Baker E, Sutherland GR . Grant Robert Sutherland . The human OTF1 locus which overlaps the CD3Z gene is located at 1q22→q23 . Cytogenet. Cell Genet. . 68 . 3–4 . 231–2 . 1995 . 7842742 . 10.1159/000133919 .
• Klemm JD, Rould MA, Aurora R, Herr W, Pabo CO . Crystal structure of the Oct–1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules . Cell . 77 . 1 . 21–32 . 1994 . 8156594 . 10.1016/0092-8674(94)90231-3 . 36371069 .
• Zwilling S, Annweiler A, Wirth T . The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP . Nucleic Acids Res. . 22 . 9 . 1655–62 . 1994 . 8202368 . 308045 . 10.1093/nar/22.9.1655 .
• Kristie TM, Sharp PA . Purification of the cellular C1 factor required for the stable recognition of the Oct–1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16) . J. Biol. Chem. . 268 . 9 . 6525–34 . 1993 . 10.1016/S0021-9258(18)53282-8 . 8454622 . free .
• Assa-Munt N, Mortishire-Smith RJ, Aurora R, Herr W, Wright PE . The solution structure of the Oct–1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain . Cell . 73 . 1 . 193–205 . 1993 . 8462099 . 10.1016/0092-8674(93)90171-L . 24276357 .
• Dekker N, Cox M, Boelens R, Verrijzer CP, van der Vliet PC, Kaptein R . Solution structure of the POU-specific DNA-binding domain of Oct–1 . Nature . 362 . 6423 . 852–5 . 1993 . 8479524 . 10.1038/362852a0 . 1993Natur.362..852D . 21540451 .
• Ström AC, Forsberg M, Lillhager P, Westin G . The transcription factors Sp1 and Oct–1 interact physically to regulate human U2 snRNA gene expression . Nucleic Acids Res. . 24 . 11 . 1981–6 . 1996 . 8668525 . 145891 . 10.1093/nar/24.11.1981 .
• Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG . The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors . J. Biol. Chem. . 272 . 47 . 29852–8 . 1997 . 9368058 . 10.1074/jbc.272.47.29852 . free .
• Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N . The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct–1 . Mol. Cell. Biol. . 18 . 1 . 368–77 . 1998 . 9418884 . 121507 . 10.1128/mcb.18.1.368.
• Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T . Interaction of Oct–1 and automodification domain of poly(ADP-ribose) synthetase . FEBS Lett. . 424 . 1–2 . 27–32 . 1998 . 9537509 . 10.1016/S0014-5793(98)00131-8 . 872132 . free . 1998FEBSL.424...27N .
• Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E, Walker P, Haché RJ . Recruitment of Octamer Transcription Factors to DNA by Glucocorticoid Receptor . Mol. Cell. Biol. . 18 . 6 . 3416–30 . 1998 . 9584182 . 108923 . 10.1128/MCB.18.6.3416.
• La Boissière S, Hughes T, O'Hare P . HCF-dependent nuclear import of VP16 . EMBO J. . 18 . 2 . 480–9 . 1999 . 9889203 . 1171141 . 10.1093/emboj/18.2.480 .

Notes and References

1. Roberts SB, Segil N, Heintz N . Differential phosphorylation of the transcription factor Oct1 during the cell cycle . Science . 253 . 5023 . 1022–6 . October 1991 . 1887216 . 10.1126/science.1887216 . 23291453 .
2. Web site: Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1.
3. Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T . Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase . FEBS Lett. . 424 . 1–2 . 27–32 . March 1998 . 9537509 . 10.1016/s0014-5793(98)00131-8. 872132 . free . 1998FEBSL.424...27N .
4. Préfontaine GG, Walther R, Giffin W, Lemieux ME, Pope L, Haché RJ . Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter . J. Biol. Chem. . 274 . 38 . 26713–9 . September 1999 . 10480874 . 10.1074/jbc.274.38.26713. free .
5. Wang JM, Préfontaine GG, Lemieux ME, Pope L, Akimenko MA, Haché RJ . Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding . Mol. Cell. Biol. . 19 . 10 . 7106–22 . October 1999 . 10490647 . 84705 . 10.1128/mcb.19.10.7106.
6. Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E, Walker P, Haché RJ . Recruitment of octamer transcription factors to DNA by glucocorticoid receptor . Mol. Cell. Biol. . 18 . 6 . 3416–30 . June 1998 . 9584182 . 108923 . 10.1128/mcb.18.6.3416.
7. La Boissière S, Hughes T, O'Hare P . HCF-dependent nuclear import of VP16 . EMBO J. . 18 . 2 . 480–9 . January 1999 . 9889203 . 1171141 . 10.1093/emboj/18.2.480 .
8. Kristie TM, Sharp PA . Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16) . J. Biol. Chem. . 268 . 9 . 6525–34 . March 1993 . 10.1016/S0021-9258(18)53282-8 . 8454622 . free .
9. Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ . The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase . J. Biol. Chem. . 276 . 20 . 16848–56 . May 2001 . 11279128 . 10.1074/jbc.M100768200 . free .
10. Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M . Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication . Biochim. Biophys. Acta . 1578 . 1–3 . 59–72 . October 2002 . 12393188 . 10.1016/s0167-4781(02)00497-9.
11. Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG . The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors . J. Biol. Chem. . 272 . 47 . 29852–8 . November 1997 . 9368058 . 10.1074/jbc.272.47.29852. free .
12. McKnight S . Gene switching by metabolic enzymes--how did you get on the invitation list? . Cell . 114 . 2 . 150–2 . July 2003 . 12887915 . 10.1016/s0092-8674(03)00563-4. 895360 . free .
13. Kakizawa T, Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J, Kumagai M, Yamashita K, Hashizume K . Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor . J. Biol. Chem. . 276 . 13 . 9720–5 . March 2001 . 11134019 . 10.1074/jbc.M008531200 . free .
14. Chasman D, Cepek K, Sharp PA, Pabo CO . Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface . Genes Dev. . 13 . 20 . 2650–7 . October 1999 . 10541551 . 317104 . 10.1101/gad.13.20.2650.
15. Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B . Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator . Biochemistry . 40 . 22 . 6580–8 . June 2001 . 11380252 . 10.1021/bi010095x.
16. van Heel DA, Udalova IA, De Silva AP, McGovern DP, Kinouchi Y, Hull J, Lench NJ, Cardon LR, Carey AH, Jewell DP, Kwiatkowski D . Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors . Hum. Mol. Genet. . 11 . 11 . 1281–9 . May 2002 . 12019209 . 10.1093/hmg/11.11.1281. free .
17. Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, Nagasawa T, Takeda T, ((Mori Ji)), Kumagai M, Hashizume K . Functional interaction between Oct-1 and retinoid X receptor . J. Biol. Chem. . 274 . 27 . 19103–8 . July 1999 . 10383413 . 10.1074/jbc.274.27.19103. free .
18. Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N . The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1 . Mol. Cell. Biol. . 18 . 1 . 368–77 . January 1998 . 9418884 . 121507 . 10.1128/mcb.18.1.368.
19. Hovde S, Brooks A, Strong K, Geiger JH . Crystallization of the Oct-1/SNAP190 peptide/DNA complex . Acta Crystallogr. D . 58 . Pt 3 . 511–2 . March 2002 . 11856838 . 10.1107/s0907444901021461.
20. Ström AC, Forsberg M, Lillhager P, Westin G . The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression . Nucleic Acids Res. . 24 . 11 . 1981–6 . June 1996 . 8668525 . 145891 . 10.1093/nar/24.11.1981.
21. Gunther M, Laithier M, Brison O . A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening . Mol. Cell. Biochem. . 210 . 1–2 . 131–42 . July 2000 . 10976766 . 10.1023/A:1007177623283. 1339642 .
22. Zwilling S, Annweiler A, Wirth T . The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP . Nucleic Acids Res. . 22 . 9 . 1655–62 . May 1994 . 8202368 . 308045 . 10.1093/nar/22.9.1655.