| Ocotepeque Department | |
| Native Name: | Departamento de Ocotepeque |
| Native Name Lang: | es |
| Settlement Type: | department |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Honduras |
| Coordinates: | 14.4333°N -100°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Honduras |
| Subdivision Type1: | Municipalities |
| Subdivision Name1: | 16 |
| Subdivision Type2: | Villages |
| Subdivision Name2: | 126 |
| Established Title: | Founded |
| Established Date: | 17 February 1906 |
| Seat Type: | Capital city |
| Seat: | Nueva Ocotepeque |
| Government Type: | Departmental |
| Leader Party: | PNH |
| Leader Title: | Gobernador |
| Leader Name: | César Osmín Arita Paz (2018-2022) |
| Unit Pref: | Metric |
| Area Total Km2: | 1636 |
| Population As Of: | 2015 |
| Population Total: | 151516 |
| Population Density Km2: | auto |
| Demographics Type1: | GDP (Nominal, 2015 US dollar) |
| Demographics1 Title1: | Total |
| Demographics1 Info1: | $500 million (2023)[1] |
| Demographics1 Title2: | Per capita |
| Demographics1 Info2: | $2,500 (2023) |
| Demographics2 Title2: | Total |
| Demographics2 Info2: | $1.0 billion (2023) |
| Demographics2 Title3: | Per capita |
| Demographics2 Info3: | $5,300 (2023) |
| Timezone1: | CDT |
| Utc Offset1: | -6 |
| Postal Code Type: | Postal code |
| Postal Code: | 43101, 43201 |
| Iso Code: | HN-OC |
| Blank Name Sec1: | HDI (2021) |
| Blank Info Sec1: | 0.589[2] · 10th of 18 |
| Footnotes: | Statistics derived from Consult INE online database: Population and Housing Census 2013[3] |
Ocotepeque is one of the 18 departments of Honduras, Central America, located in the West and bordering both El Salvador and Guatemala. It was formed in 1906 from part of Copán department. The capital and main city is Nueva Ocotepeque.
The department covers a total surface area of 1,630 km² and, in 2015, had an estimated population of 151,516.