| Obdulio Barthe | |
| Birth Date: | 5 September 1903 |
| Birth Place: | Encarnación, Paraguay |
| Death Place: | Buenos Aires, Argentina |
| Occupation: | Politician |
| Years Active: | 1920–1981 |
| Known For: | Encarnación Commune |
Obdulio Barthe (Encarnación; September 5, 1903 – Buenos Aires; 1981) was a Paraguayan Communist and syndicalist politician. In 1931, he was one of the leaders in the Encarnación Commune.