Obafluorin Explained

Obafluorin is a β-lactone antibiotic with the molecular formula C₁₇H₁₄N₂O₇.^{[1] [2]} Obafluorin is produced by the bacterium Pseudomonas fluorescens.^[3] Obafluorin is a inhibitor of serine hydroxymethyltransferase.^[4]

Further reading

• Next antibiotic may come from dirt bacteria . Futurity . 2 August 2019.
• Scott . Thomas A. . Heine . Daniel . Qin . Zhiwei . Wilkinson . Barrie . An L-threonine transaldolase is required for L-threo-β-hydroxy-α-amino acid assembly during obafluorin biosynthesis . Nature Communications . 26 June 2017 . 8 . 1 . 15935 . 10.1038/ncomms15935 . 28649989 . 5490192 . en . 2041-1723.
• Herbert . Richard B. . Knaggs . Andrew R. . Biosynthesis of the antibiotic obafluorin from D-[U-¹³C]glucose and p-aminophenylalanine in Pseudomonas fluorescens . Journal of the Chemical Society, Perkin Transactions 1 . 1992 . 1 . 103–107 . 10.1039/P19920000103 . en . 1364-5463.

Notes and References

1. Scott . Thomas A. . Batey . Sibyl F. . Wiencek . Patrick . Chandra . Govind . Alt . Silke . Franklyn . Christopher S. . Wilkinson . Barrie . Self-immunity guided identification of threonyl-tRNA synthetase as the molecular target of obafluorin, a β-lactone antibiotic . 17 July 2019 . 10.1101/704981 . bioRxiv. 201196822 .
2. Tymiak . Adrienne A. . Culver . Catherine A. . Malley . Mary F. . Gougoutas . Jack Z. . Structure of obafluorin: an antibacterial β-lactone from Pseudomonas fluorescens . Journal of Organic Chemistry . December 1985 . 50 . 26 . 5491–5495 . 10.1021/jo00350a010.
3. Wells . J. Scott . Trejo . William H. . Principe . Pacifico A. . Sykes . Richard B. . Obafluorin, a novel β-lactone produced by Pseudomonas fluorescens. Taxonomy, fermentation and biological properties. . Journal of Antibiotics . 1984 . 37 . 7 . 802–803 . 10.7164/antibiotics.37.802. 6432765 . free .
4. Prasad . Neha . Obafluorin: A Potential Inhibitor of Serine Hydroxymethyl |expected=Transferase}} ]. Undergraduate Research Symposium Posters . 18 April 2015 .