OTX1 explained

Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene.^{[1] [2]}

Function

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. The Otx gene is active in the region of the first gill arch, which is related to the upper and lower jaw and two of the bones of the ear.^[3] A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.

Further reading

• Simeone A, Acampora D, Mallamaci A, Stornaiuolo A, D'Apice MR, Nigro V, Boncinelli E . A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo . The EMBO Journal . 12 . 7 . 2735–47 . July 1993 . 8101484 . 413524 . 10.1002/j.1460-2075.1993.tb05935.x.
• Acampora D, Mazan S, Avantaggiato V, Barone P, Tuorto F, Lallemand Y, Brûlet P, Simeone A . Epilepsy and brain abnormalities in mice lacking the Otx1 gene . Nature Genetics . 14 . 2 . 218–22 . October 1996 . 8841200 . 10.1038/ng1096-218 . 32251856 .
• Nagao T, Leuzinger S, Acampora D, Simeone A, Finkelstein R, Reichert H, Furukubo-Tokunaga K . Developmental rescue of Drosophila cephalic defects by the human Otx genes . Proceedings of the National Academy of Sciences of the United States of America . 95 . 7 . 3737–42 . March 1998 . 9520436 . 19906 . 10.1073/pnas.95.7.3737 . 1998PNAS...95.3737N . free .
• Weimann JM, Zhang YA, Levin ME, Devine WP, Brûlet P, McConnell SK . Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets . Neuron . 24 . 4 . 819–31 . December 1999 . 10624946 . 10.1016/S0896-6273(00)81030-2 . 407402 . free .
• Francks C, Fisher SE, Olson RK, Pennington BF, Smith SD, DeFries JC, Monaco AP . Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1 . Psychiatric Genetics . 12 . 1 . 35–41 . March 2002 . 11901358 . 10.1097/00041444-200203000-00005 . 11858/00-001M-0000-0012-C9C5-5 . 15050388 . free .
• Puelles E, Annino A, Tuorto F, Usiello A, Acampora D, Czerny T, Brodski C, Ang SL, Wurst W, Simeone A . Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain . Development . 131 . 9 . 2037–48 . May 2004 . 15105370 . 10.1242/dev.01107 . free .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E . Chromosome locations of human EMX and OTX genes . Genomics . 22 . 1 . 41–5 . July 1994 . 7959790 . 10.1006/geno.1994.1343 .
2. Web site: Entrez Gene: OTX1 orthodenticle homeobox 1.
3. Shubin, Neil "Your Inner Fish" 2009