OSTbeta explained

Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.^{[1] [2]}

Function

OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.^{[2] [3]} The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.^[3] The heterodimer furthermore is essential for intestinal bile acid transport.^[4]

OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.^[2]

See also

• OSTalpha
• OST Family
• Transporter Classification Database

Further reading

• Sun AQ . Protein-protein interactions and membrane localization of the human organic solute transporter . Am. J. Physiol. Gastrointest. Liver Physiol. . 292 . 6 . G1586–93 . 2007 . 17332473 . 10.1152/ajpgi.00457.2006 . vanc. Balasubramaniyan N . Xu K . 3 . Liu . C. J. . Ponamgi . V. M. . Liu . H. . Suchy . F. J. .
• Boyer JL . Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents . Am. J. Physiol. Gastrointest. Liver Physiol. . 290 . 6 . G1124–30 . 2006 . 16423920 . 10.1152/ajpgi.00539.2005 . vanc. Trauner M . Mennone A . 3 . Soroka . CJ . Cai . SY . Moustafa . T . Zollner . G . Lee . JY . Ballatori . N . 86156271 .
• Ballatori N . OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia . Hepatology . 42 . 6 . 1270–9 . 2005 . 16317684 . 10.1002/hep.20961 . vanc. Christian WV . Lee JY . 3 . Dawson . Paul A. . Soroka . Carol J. . Boyer . James L. . Madejczyk . Michael S. . Li . Na . free .
• Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA . The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes . Am. J. Physiol. Gastrointest. Liver Physiol. . 290 . 3 . G476–85 . 2006 . 16269519 . 10.1152/ajpgi.00430.2005 . 8687386 .
• Lee H . FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine . J. Lipid Res. . 47 . 1 . 201–14 . 2006 . 16251721 . 10.1194/jlr.M500417-JLR200 . vanc. Zhang Y . Lee FY . 3 . Nelson . SF . Gonzalez . FJ . Edwards . PA . free.
• Dawson PA . The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter . J. Biol. Chem. . 280 . 8 . 6960–8 . 2005 . 15563450 . 10.1074/jbc.M412752200 . 1224727 . vanc. Hubbert M . Haywood J . 3 . Craddock . AL . Zerangue . N . Christian . WV . Ballatori . N . free .
• Seward DJ, Koh AS, Boyer JL, Ballatori N . Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta . J. Biol. Chem. . 278 . 30 . 27473–82 . 2003 . 12719432 . 10.1074/jbc.M301106200 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .

Notes and References

1. Web site: Entrez Gene: OSTbeta organic solute transporter beta.
2. Seward DJ, Koh AS, Boyer JL, Ballatori N . Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta . J. Biol. Chem. . 278 . 30 . 27473–82 . July 2003 . 12719432 . 10.1074/jbc.M301106200 . free .
3. Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N . The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter . J. Biol. Chem. . 280 . 8 . 6960–8 . February 2005 . 15563450 . 1224727 . 10.1074/jbc.M412752200 . free .
4. Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA . The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis . Proc. Natl. Acad. Sci. U.S.A. . 105 . 10 . 3891–6 . March 2008 . 18292224 . 2268840 . 10.1073/pnas.0712328105 . 2008PNAS..105.3891R . free .