OSBPL2 explained

Oxysterol-binding protein-related protein 2 is a protein that in humans is encoded by the OSBPL2 gene.^{[1] [2] [3]}

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.^[4]

Further reading

• Nagase T, Ishikawa K, Suyama M, etal . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 5 . 5 . 277–86 . 1999 . 9872452 . 10.1093/dnares/5.5.277 . free .
• Xu Y, Liu Y, Ridgway ND, McMaster CR . Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. . J. Biol. Chem. . 276 . 21 . 18407–14 . 2001 . 11279184 . 10.1074/jbc.M101204200 . free .
• Lehto M, Laitinen S, Chinetti G, etal . The OSBP-related protein family in humans. . J. Lipid Res. . 42 . 8 . 1203–13 . 2001 . 10.1016/S0022-2275(20)31570-4 . 11483621 . free .
• Jaworski CJ, Moreira E, Li A, etal . A family of 12 human genes containing oxysterol-binding domains. . Genomics . 78 . 3 . 185–96 . 2002 . 11735225 . 10.1006/geno.2001.6663 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E . Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism . J Lipid Res . 40 . 12 . 2204–11 . Feb 2000 . 10.1016/S0022-2275(20)32095-2 . 10588946 . free .
2. Laitinen S, Lehto M, Lehtonen S, Hyvarinen K, Heino S, Lehtonen E, Ehnholm C, Ikonen E, Olkkonen VM . ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism . J Lipid Res . 43 . 2 . 245–55 . Feb 2002 . 10.1016/S0022-2275(20)30166-8 . 11861666 . free .
3. Web site: Entrez Gene: OSBPL2 oxysterol binding protein-like 2.
4. Web site: Entrez Gene: OSBPL2 oxysterol binding protein-like 2.