ORM1 explained

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.^[1]

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.^[1]

Interactions

ORM1 has been shown to interact with Plasminogen activator inhibitor-1.^[2]

See also

• Orosomucoid

Further reading

• Treuheit MJ, Costello CE, Halsall HB . Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein. . Biochem. J. . 283 . 1. 105–12 . 1992 . 1567356 . 10.1042/bj2830105. 1131000 .
• Dente L, Ciliberto G, Cortese R . Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes. . Nucleic Acids Res. . 13 . 11 . 3941–52 . 1985 . 2409529 . 10.1093/nar/13.11.3941 . 341288 .
• Dubé JY, Paradis G, Têtu B, Tremblay RR . Synthesis of alpha 1-acid glycoprotein by the human prostate. . Prostate . 15 . 3 . 251–8 . 1989 . 2479939 . 10.1002/pros.2990150305 . 84445745 .
• Zuffardi O, Caiulo A, Maraschio P, etal . Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter? . Hum. Genet. . 82 . 1 . 17–9 . 1989 . 2541064 . 10.1007/bf00288264. 42021177 .
• Dente L, Pizza MG, Metspalu A, Cortese R . Structure and expression of the genes coding for human alpha 1-acid glycoprotein. . EMBO J. . 6 . 8 . 2289–96 . 1987 . 2822385 . 10.1002/j.1460-2075.1987.tb02503.x. 553631 .
• Merritt CM, Board PG . Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene. . Gene . 66 . 1 . 97–106 . 1988 . 2970990 . 10.1016/0378-1119(88)90228-4 .
• Dente L, Rüther U, Tripodi M, etal . Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice. . Genes Dev. . 2 . 2 . 259–66 . 1988 . 3360326 . 10.1101/gad.2.2.259 . free .
• Rocchi M, Roncuzzi L, Santamaria R, etal . Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9. . Hum. Genet. . 74 . 1 . 30–3 . 1986 . 3463531 . 10.1007/BF00278781 . 34725840 .
• Board PG, Jones IM, Bentley AK . Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA. . Gene . 44 . 1 . 127–31 . 1986 . 3770479 . 10.1016/0378-1119(86)90051-X .
• Krauss E, Polnaszek CF, Scheeler DA, etal . Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera. . J. Pharmacol. Exp. Ther. . 239 . 3 . 754–9 . 1987 . 3795040 .
• Ikenaka T, Ishiguro M, Emura J, etal . Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment. . Biochemistry . 11 . 20 . 3817–29 . 1972 . 4561179 . 10.1021/bi00770a022 .
• Schmid K, Bürgi W, Collins JH, Nanno S . The disulfide bonds of alpha1-acid glycoprotein. . Biochemistry . 13 . 13 . 2694–7 . 1974 . 4603214 . 10.1021/bi00710a006 .
• Schmid K, Kaufmann H, Isemura S, etal . Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins. . Biochemistry . 12 . 14 . 2711–24 . 1973 . 4711474 . 10.1021/bi00738a026 .
• Mbuyi JM, Dequeker J, Bloemmen F, Stevens E . Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE. . Calcif. Tissue Int. . 34 . 3 . 229–31 . 1982 . 6809283 . 10.1007/BF02411242 . 13305518 .
• Rabehi L, Ferriere F, Saffar L, Gattegno L . alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans. . Glycoconj. J. . 12 . 1 . 7–16 . 1995 . 7795416 . 10.1007/BF00731863 . 23508679 . free .
• Matoba R, Okubo K, Hori N, etal . The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. . Gene . 146 . 2 . 199–207 . 1994 . 8076819 . 10.1016/0378-1119(94)90293-3 .
• Nakamura T, Board PG, Matsushita K, etal . Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis. . Inflammation . 17 . 1 . 33–45 . 1993 . 8432561 . 10.1007/BF00916390 . 2027.42/44509 . 6012698 . free .
• Yuasa I, Umetsu K, Vogt U, etal . Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S. . Hum. Genet. . 99 . 3 . 393–8 . 1997 . 9050929 . 10.1007/s004390050378 . 21298011 .
• Morin D, Simon N, Deprés-Brummer P, etal . Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum. . Pharmacology . 54 . 5 . 271–5 . 1997 . 9380773 . 10.1159/000139495 .
• Nakamura H, Yuasa I, Umetsu K, etal . The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2. . Biochem. Biophys. Res. Commun. . 276 . 2 . 779–84 . 2000 . 11027547 . 10.1006/bbrc.2000.3522 .

Notes and References

1. Web site: Entrez Gene: ORM1 orosomucoid 1.
2. Boncela . J . Papiewska I . Fijalkowska I . Walkowiak B . Cierniewski C S . Sep 2001 . Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity . J. Biol. Chem. . 276 . 38 . 35305–11 . United States. 0021-9258. 11418606 . 10.1074/jbc.M104028200 . free .