ORG-37684 explained

ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.[1] [2] It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans.[3]

See also

Notes and References

  1. 10.1081/SCC-100104420. 2001. Adams D, Duncton M . Efficient Synthesis of the 5-Ht2C Receptor Agonist, Org 37684 . Synthetic Communications. 31. 13. 2029–2036 . 83706335.
  2. Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M . Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors . Naunyn-Schmiedeberg's Archives of Pharmacology . 370 . 2 . 114–23 . August 2004 . 15322733 . 10.1007/s00210-004-0951-4 . 8938111 .
  3. Schreiber R, De Vry J . Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat . Progress in Neuro-Psychopharmacology & Biological Psychiatry . 26 . 3 . 441–9 . April 2002 . 11999893 . 10.1016/s0278-5846(01)00284-6 . 25689931 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ORG-37684".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.