OR52D1 explained

Olfactory receptor 52D1 is a protein that in humans is encoded by the OR52D1 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Ligands

Compared to other olfactory receptors such as OR1G1, OR52D1 has a more narrow/specific range of ligands.^[2]

Agonists:

• Methyl octanoate^[2]
• "Better activated by acids, aldehydes, ketones and esters than alcohols or pyrazines"^[2]

See also

• Olfactory receptor

Further reading

• Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH . 6 . Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes . Proceedings of the National Academy of Sciences of the United States of America . 96 . 9 . 5129–34 . April 1999 . 10220430 . 21828 . 10.1073/pnas.96.9.5129 . 1999PNAS...96.5129B . free .
• Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R . 6 . Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters . Proceedings of the National Academy of Sciences of the United States of America . 97 . 26 . 14560–5 . December 2000 . 11121057 . 18958 . 10.1073/pnas.97.26.14560 . 2000PNAS...9714560B . free .
• Malnic B, Godfrey PA, Buck LB . The human olfactory receptor gene family . Proceedings of the National Academy of Sciences of the United States of America . 101 . 8 . 2584–9 . February 2004 . 14983052 . 356993 . 10.1073/pnas.0307882100 . 2004PNAS..101.2584M . free .

Notes and References

1. Web site: Entrez Gene: OR52D1 olfactory receptor, family 52, subfamily D, member 1.
2. Sanz G, Schlegel C, Pernollet JC, Briand L . Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism . Chemical Senses . 30 . 1 . 69–80 . January 2005 . 15647465 . 10.1093/chemse/bji002 . free .